2014 Fiscal Year Final Research Report
Analysis of volatile organic compounds in feces for the development of diagnostic biomarkers of lifestyle-related diseases
| Project/Area Number |
25560057
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Yuko 静岡県立大学, 食品栄養科学部, 助教 (00580523)
TOMONO Susumu 静岡県立大学, 食品栄養科学部, 客員共同研究員 (60554011)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 揮発性有機化合物 / 腸内細菌叢 / メタボローム解析 |
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| Outline of Final Research Achievements |
It is strongly suggested that intestinal microflora is playing pivotal roles in metabolic homeostasis. However some factors, stress, aging, and dietary pattern, possibly influence the intestinal microflora, which deteriorated composition possibly triggers the low-level but chronic inflammation associated with several lifestyle-related diseases including obesity and diabetic mellitus. In this study, to evaluate the possible association between the pathogenesis of lifestyle-related diseases and volatile organic compounds (VOCs) in intestinal tract, VOCs in feces derived from obese and diabetic model mice KK-Ay and their control (C57BL/6J mice) fed with normal or high fat diet were analyzed using a headspace sampler-GC-MS. We found that several VOCs were significantly increased in KK-Ay and/or high-fat diet fed mice, which were then identified acetone, phenol, and nonanal.
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| Free Research Field |
食品分析化学
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