Development of nutrients to repair and regenerate the 3-D structure of skeletal muscle and capillary

2016 Fiscal Year Final Research Report

• Project/Area Number: 25560065
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Nagoya Women's University
• Principal Investigator: Kondo Hiroyo 名古屋女子大学, 家政学部, 准教授 (50333183)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 骨格筋 / 食品成分 / 筋減弱 / 微小血管

Outline of Final Research Achievements

The purpose of the present study was to explore the effects of nutrients on the changes of the three-dimensional capillary networks and myofibers in the skeletal muscle. Nucleoprotein and lemon myrtle supplementation attenuated muscle atrophy and increased satellite cell activation via up-regulation in the expression level of Pax7, MyoD, myogenin, and the phosphorylation of Akt-1 and p70S6k. In addition, the velocity of red blood cells was faster 20, 40, and 60 min after than before the administration of Enterococcus faecium strain R30. This effect was suppressed by propranolol administration. R30 supplementation increased capillary luminal diameter and volume and eNOS and VEGF protein levels in the skeletal muscle under disuse. Also, astaxanthin supplementation　attenuated the capillary regression of skeletal muscle. These results indicate nutrients supplementation may be a useful strategy to use for conditions involving muscle dysfunction.

Free Research Field

骨格筋、微小血管、栄養科学、リハビリテーション、スポーツ