Development of novel microchannel device for cell migration with micropillar array

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560187
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Hokkaido University
• Principal Investigator: Ohashi Toshiro 北海道大学, 工学(系)研究科(研究院), 教授 (30270812)
• Research Collaborator: Cooper-White Justin The University of Melbourne, Prof.
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: バイオメカニクス / 細胞遊走 / マイクロデバイス

Outline of Final Research Achievements

Cell migration is known to play an important role in a number of physiological events in living body such as morphogenesis, wound healing, and tumor metastasis. It is therefore important to study the mechanism of cell migration from the viewpoint of mechanics. The objective of this study is to newly design and fabricate a multichannel device integrated with micropillar technology to evaluate cell traction forces during cell migration. The multichannel device has been successfully fabricated, which allows to modulate cell migration rate by changing the stiffness of micropillars and by giving the micropillars anisotropic properties.

Free Research Field

バイオメカニクス