Development of Innovative Intubation Tube inducing Less-Ventilator-associated pneumonia

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560192
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokyo
• Principal Investigator: CHUNG Ung-il 東京大学, 工学(系)研究科(研究院), 教授 (30345053)
• Co-Investigator(Kenkyū-buntansha): SHIMOHATA Nobuyuki 立命館大学, 生命科学部, 助教 (30419709)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 人工呼吸関連肺炎 / 可塑剤溶出抑制

Outline of Final Research Achievements

In this study, we aimed to suppress ventilator-associated pneumonia by coating commercial intubation tubes with MPC, which is a biocompatible polymer. We investigated a coating efficiency and a suppressive effect on elution, and decided an appropriate coating condition.
We also found that DEHP (Di-(ethylhexyl)phthalate), the most famous plasticizer used in medical plastics, induced pro-inflammatory response in a dose dependent manner. It means that the coating with MPC can reduce plasticizers-possessing toxicity in clinical use.

Free Research Field

医工学