In vivo evaluation of immune responses and inflammation against biomaterials by global gene analysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560218
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KAKINOKI Sachiro 独立行政法人国立循環器病研究センター, 研究所, 研究員 (70421419)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: バイオマテリアル / 炎症 / 免疫反応 / バイオイナート / ＭＰＣポリマー / 多孔質体 / 細胞浸潤 / 遺伝子網羅解析

Outline of Final Research Achievements

Recently, medical devices such as artificial organs and prosthetic implants are widely used for clinical practices. When these artificial materials are implanted into living body, the foreign body reactions are induced. The foreign body reactions against device implantation is different them against virus infection, and their biological mechanism have not been clarified yet. In this study, we analyzed the host responses against porous polyethylene scaffolds coated with MPC polymer, which is widely used as bioinert polymer, in the gene level. The results of gene level analyses suggested that the initial inflammation is strongly inhibited and delayed by MPC polymer coating.

Free Research Field

バイオマテリアル、タンパク質化学、ペプチド化学