Challenging exploratory researches on in vivo microfabrication techniques by combining nanotechnologies and cell recruiting techniques

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560221
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto University
• Principal Investigator: YAMAMOTO Masaya 京都大学, 再生医科学研究所, 准教授 (10332735)
• Co-Investigator(Kenkyū-buntansha): TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ナノテクノロジー / 微細加工 / 血管新生 / 細胞動員 / 血管吻合

Outline of Final Research Achievements

In this study, we developed two technologies, including in vivo angiogenesis induced in a spatially controlled manner (subject 1) and recruitment of angiogenic cells from cell tissue-like constructs (subject 2). In the subject 1, we demonstrated that the controlled release of angiogenic growth factors from biodegradable micro and/or nano particles could induce the in vivo angiogenesis. On the contrary, in the subject 2, we developed a stimuli-responsive material that allows vascular endothelial cells to be positioned into cell tissue-like constructs in an efficient and spatially controlled manner. The material can be fabricated in the desired shape, and vascular endothelial cells can attach on the surface of the material. Upon using the material with vascular endothelial cells, we fabricated cell tissue-like constructs with vascular-like structures.

Free Research Field

生体材料学、再生医療、幹細胞工学