2013 Fiscal Year Final Research Report
Pancreatic cancer specific targeting by protein nanocages
| Project/Area Number |
25560225
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyushu University |
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Principal Investigator |
MURATA Masaharu 九州大学, 学内共同利用施設等, 准教授 (30304744)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIZUME Makoto 九州大学, 大学院・医学研究院, 教授 (90198664)
KAWANO Takahito 九州大学, 先端融合医療レドックスナビ, 特任助教 (90526831)
HAMANO Nobuhito 九州大学, 先端医療イノベーションセンター, 特任助教 (80708397)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | ナノ材料 / DDS / 分子イメージング |
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| Research Abstract |
Protein nanocages are self-organized complexes of oligomers whose three-dimensional architecture can been determined in detail. These structures possess nanoscale inner cavities into which a variety of molecules, including therapeutic or diagnostic agents, can be encapsulated. These properties yield these particles suitable for a new class of drug delivery carrier, or as a bioimaging reagent that might respond to biochemical signals in many different cellular processes. We report here the design, synthesis, and biological characterization of a Pancreatic cancer nanocage carrying small heat-shock protein. These nanoscale protein cages, with a targeting peptide on their surfaces, were prepared by genetic engineering techniques. iRGD-carrying nanocages showed lower cytotoxicity and significantly higher specificity for human pancreatic cancer cell lines than other cell lines in vitro.
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[Journal Article] Mass Spectrometry-Based Metabolic Profiling of Gemcitabine-Sensitive and Gemcitabine-Resistant Pancreatic Cancer Cells2014
Author(s)
Yoshinori Fujimura, Naoki Ikenaga, Kenoki Ohuchida, Daiki Setoyama, Miho Irie, Daisuke Miura, Hiroyuki Wariishi, Masaharu Murata, Kazuhiro Mizumoto, Makoto Hashizume, Masao Tanaka
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Journal Title
Pancreas
Volume: 43
Pages: 311-318
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[Journal Article] Intraoperative visualization of cerebral oxygenation using hyperspectral image data : a two-dimensional mapping method
Author(s)
Megumu Mori, Toru Chiba, Akira Nakamizo, Ryuichi Kumashiro, Masaharu Murata, Tomohiko Akahoshi, Morimasa Tomikawa, Yuichirou Kikkawa, Koji Yoshimoto, Masahiro Mizoguchi, Tomio Sasaki, Makoto Hashizume
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Journal Title
International Journal of Computer Assisted Radiology and Surgery
Volume: (in press)
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