Development of porous scaffolds with micropatterned bioactive molecules

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560229
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institute for Materials Science
• Principal Investigator: KAWAZOE Naoki 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (90314848)
• Co-Investigator(Renkei-kenkyūsha): CHEN Guoping 物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, ユニット長 (50357505)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 再生医工学材料

Outline of Final Research Achievements

Porous scaffolds with micropatterned structures are a promising tool for the regeneration of functional tissues, because they can mimic the biological and physiochemical factors in the in vivo cell microenvironments. Here we developed a method to micropattern bioactive molecules in porous collagen scaffolds by the combination of dispensing technique and freeze drying. Frozen micropatterns of the mixture of collagen and bioactive molecules solutions were used as templates to introduce bioactive molecules into the porous scaffolds. The distribution of bioactive molecules was spatially controlled by the micropatterns tethered by designing a computer program. The micropatterned porous scaffolds will be useful for spatially guided tissue regeneration.

Free Research Field

高分子生体材料学