Development of an integrated endoscopic system based on optical imaging and hyper-spectral data analysis for early gastrointestinal cancer detection

2013 Fiscal Year Final Research Report

• Project/Area Number: 25560238
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Kyushu University
• Principal Investigator: TOMIKAWA Morimasa 九州大学, 大学病院, 特任准教授 (60325454)
• Co-Investigator(Kenkyū-buntansha): AKAHOSHI Tomohiko 九州大学, 医学研究院, 講師 (20336019) ; MURATA Masaharu 九州大学, 先端融合医療レドックスナビ研究拠点, 准教授 (30304744) ; HASHIZUME Makoto 九州大学, 医学研究院, 教授 (90198664)
• Co-Investigator(Renkei-kenkyūsha): KUMASHIRO Ryuichi 九州大学, 大学病院, 医員 (10631591)
• Project Period (FY): 2013-04-01 – 2014-03-31
• Keywords: 画像診断システム / 分光学的解析

Research Abstract

We examined a possibility of our developed hyper spectral camera system for a diagnosis of colorectal cancer. During the endoscopic screening, hyper spectral camera by which the reflectance spectral data of 400-800nm for 640x480 pixels are captured. All lesions that appeared abnormal and normal mucosa around the lesion were targeted. Resected specimens of primary colorectal cancer and non-neoplastic mucosa were obtained and measured spectrum at several points of the colorectal mucosa. We evaluated accuracy of the ability for tumor detection by the hyper spectral camera system. The average reflection intensity rate of each categories are, normal mucosa; 0.96, hyperplastic polyp; 0.90, adenoma; 0.86 and adenocarcinoma; 0.60. The increased spectral absorption ex vivo at 510nm was observed. Tumor and non-tumor tissue could be discriminated with a sensitivity of 62-75% and a specificity of 83-85% in both in vivo and ex vivo experiment.

Research Products

• [Journal Article] Merits of prophylactic sclerotherapy for esophageal varices concomitant unresectable hepatocellular carcinoma : Prospective randomized study (2014)
  • Author(s): Akahoshi T, Tomikawa M, Tsutsumi N, Hashizume M, Maehara Y
  • Journal Title: Digestive Endoscopy Volume: 26(2) Pages: 172-177
• [Journal Article] 胆膵膵臓胆道疾患のNOTES現状と将来 (2013)
  • Author(s): 富川盛雅, 橋爪誠
  • Journal Title: Annual Review 消化器 Volume: 2013巻 Pages: 273-279
• [Journal Article] 計算解剖モデルに基づくナビゲーション手術の最前線 (2013)
  • Author(s): 富川盛雅, 橋爪誠
  • Journal Title: MEDICAL IMAGING TECHNOLOGY Volume: 31(5) Pages: 311-316
• [Journal Article] 医用画像を応用したナビゲーション手術・低侵襲治療シミュレーションの有用性の検討 (2013)
  • Author(s): 富川盛雅, 植村宗則, 長尾吉泰, 金城直, 堤敬文, 赤星朋比古, 前田貴司, 川中博文, 田上和夫, 森健策, 池田哲夫, 前原喜彦, 橋爪誠
  • Journal Title: 臨床と研究 Volume: 90(12) Pages: 205-210
• [Journal Article] IEEE : Objective Skill Evaluation for Laparoscopic Training Based on Motion Analysis (2013)
  • Author(s): Zhuohua L, Uemura M, Zecca M, IEEE, Sessa S, Member, IEEE, Isii H, Tomikawa M, Hashizume M, Yamaguchi S, Yoshida D, Takanishi A, Member
  • Journal Title: IEEE Transaction on Biomedecal Engineering Volume: 60(4) Pages: 977-85
• [Journal Article] Three-Dimensional High-Definition Neuroendoscopic Surgery : A Controlled Comparative Laboratory Study with Two-Demensional Endoscopy and Clinical Application (2013)
  • Author(s): Inoue D, Yoshimoto K, Uemura M, Yoshida M, Ohuchida K, Kenmotsu H, Tomikawa M, Sasaki T, Hashizume M
  • Journal Title: J Neuril Surg A Volume: 74 Pages: 357-365
• [Journal Article] Treatment of Bleeding Rectal Varices With Transumbilical Venous Obliteration of the Inferior Mesenteric Vein (2013)
  • Author(s): Hashimoto N, Akahoshi T, Kamori M, Tomikawa M, Yoshida D, Nagao Y, Morita K, Kayashima H, Ikegami T, Yoshizumi T, Taketomi A, Shirabe K, Maehara Y
  • Journal Title: Surg Laparosc Endosc Percutan Tech Volume: 23(3) Pages: 134-137
• [Journal Article] Development of an objective endoscopic surgical skill assessment system for pediatric surgeons : suture ligature model of the crura of the diaphragm in infant fundoplication (2013)
  • Author(s): Ieiri S, Ishii H, Souzaki R, Uemura M, Tomikawa M, Matsuoka N, Takanishi A, Hashizume M, Taguchi T
  • Journal Title: Pediatr Surg Int Volume: 29(5) Pages: 501-4
• [Journal Article] Balloon-occluded retrograde transvenous obliteration is feasible for prolonged portosystemic shunts after living donor liver transplantation (2013)
  • Author(s): Nagao Y, Akahoshi T, Uehara U, Hashimoto N, Kinjo N, Kawanaka H, Tomikawa M, Uchiyama H, Yoshizumi T, Soejima Y, Shirabe K, Maehara Y
  • Journal Title: Surgery Today Volume: 44(4) Pages: 633-639
• [Journal Article] Image-guided laparoscopic surgery in an open MRI operating theater (2013)
  • Author(s): Tsutsumi N, Tomikawa M, Uemura M, Akahoshi T, Nagao Y, Konishi K, Ieiri S, Hong J, Maehara Y, Hashizume M
  • Journal Title: Surg Endosc Volume: 27(6) Pages: 2178-2184
• [Journal Article] 医用画像に基づく計算解剖学の消化器外科領域への応用 (2013)
  • Author(s): 赤星朋比古, 富川盛雅, 橋爪誠
  • Journal Title: MEDICAL PHOTONICS Volume: 2013夏 No. 14 Pages: 17-21
• [Journal Article] The Effect of Proton Pomp Inhibitor(PPI : Rabeprazole) on Reflux Esophagitis after Endoscopic Injection Sclerotherapy(EIS), a Randomized Control Study(24 hour-pH monitoring). (2013)
  • Author(s): Akahoshi T, Kawanaka H, Tomikawa M, Saeki H, Uchiyama H, Ikeda T, Shirabe K, Hashizume M, Maehara Y
  • Journal Title: Fukuoka Acta Med Volume: 104(12) Pages: 483-489
• [Journal Article] An augmented reality navigation sysytem for pediatric oncologic surgery based on preoperative CT and MRI images (2013)
  • Author(s): Souzaki R, Ieiri S, Uemura M, Ouchida K, Tomikawa M, Kioshita Y, Koga Y, Suminoe A, Kohashi K, Oda Y, Hara T, Hashizume M, Taguchi T
  • Journal Title: Journal of Pediatric Surgery Volume: (48) Pages: 2479-2483
• [Journal Article] カオス解析を用いた内視鏡外科手術における鉗子先端動作解析~熟練者と初心者の潜在的な動きのちがい~ (2013)
  • Author(s): 植村宗則, 富川盛雅, 苗鉄軍, 家入里志, 宗崎良太, 大内田研宙, 橋爪誠
  • Journal Title: 日本コンピュータ外科学会誌 Volume: 15(2) Pages: 218-219
• [Presentation] 腹腔鏡下袖状胃切除術における3D内視鏡・ViKYシステム・循環式気腹装置(エアシール)の有用性の検討 (2013)
  • Author(s): 富川盛雅, 神代竜一, 長尾吉泰, 赤星朋比古, 田井耕二, 大内田研宙, 家入里志, 池田哲夫, 是永大輔, 竹中賢治, 橋爪誠
  • Organizer: 第26回日本内視鏡外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20131128-30
• [Presentation] 九州大学病院における肥満手術の工夫-立体映像表示システムを用いた腹腔鏡下袖状胃切除術- (2013)
  • Author(s): 富川盛雅, 神代竜一, 長尾吉泰, 赤星朋比古, 田井耕二, 大内田研宙, 家入里志, 池田哲夫, 是永大輔, 竹中賢治, 橋爪誠
  • Organizer: 第26回日本内視鏡外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20131128-30
• [Presentation] 内視鏡外科手術における客観的消化管縫合技術評価シミュレータの開発 (2013)
  • Author(s): 富川盛雅, 植村宗則, 布施健一, 松岡利之, 大内田研宙, 赤星朋比古, 宗崎良太, 家入里志, 是永大輔, 竹中賢治, 橋爪誠
  • Organizer: 第26回日本内視鏡外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20131128-30
• [Presentation] 経済効果と患者の生活の質の向上を考慮した単孔式TEP法 (2013)
  • Author(s): 富川盛雅, 神代竜一, 東貴寛, 赤星朋比古, 森田和豊, 江口大彦, 遠藤和也, 奥山稔郎, 立石雅宏, 内山秀昭, 是永大輔, 橋爪誠, 竹中賢治
  • Organizer: 第75回日本臨床外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20131121-23
• [Presentation] 腹腔鏡下脾臓摘出術における工夫ー軟性内視鏡併用の試みー (2013)
  • Author(s): 富川盛雅, 赤星朋比古, 金城直, 上原英雄, 橋本直隆, 長尾吉泰, 前原喜彦, 橋爪誠
  • Organizer: 第20回日本門脈圧亢進症学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20130919-20
• [Presentation] 内視鏡外科手術トレーニングセミナーの有効性-受講者に対するアンケート結果を加味した解析- (2013)
  • Author(s): 富川盛雅, 植村宗則, 神代竜一, 森恩, 宗崎良太, 大内田研宙, 赤星朋比古, 家入里志, 大平猛, 池田哲夫, 橋爪誠
  • Organizer: 第22回日本コンピュータ外科学会大会
  • Place of Presentation: 東京
  • Year and Date: 20130914-16
• [Presentation] Reduced Port SurgeryのProsに適うアドバンストトレーニングの試み (2013)
  • Author(s): 富川盛雅, 植村宗則, 大内田研宙, 赤星朋比古, 家入里志, 大平猛, 橋爪誠
  • Organizer: Reduced Port Surgery Forum in Morioka
  • Place of Presentation: 盛岡
  • Year and Date: 20130802-03
• [Presentation] 内視鏡外科手術基本手技の定量的分析と効果的なトレーニング法の開発 (2013)
  • Author(s): 富川盛雅, 植村宗則, 神代竜一, 宗崎良太, 大内田研宙, 赤星朋比古, 石井裕之, 家入里志, 大平猛, 橋爪誠
  • Organizer: 第68回日本消化器外科学会総会
  • Place of Presentation: 宮崎
  • Year and Date: 20130717-19
• [Presentation] Catheterization for balloon-occluded retrograde transvenous obliteration guided by fly-through module of New Virtual Endoscopic System (2013)
  • Author(s): Tomikawa M, Akahoshi T, Oda M, Kumashiro R, Uemura M, Ieiri S, Mori K, Hashizume M
  • Organizer: Computer Asisted Radiology and Surgery 27th International Congress and Exhibition
  • Place of Presentation: Heidelberg, Germany
  • Year and Date: 20130626-29
• [Presentation] 受講者に対するアンケート結果からみた内視鏡外科手術基本手技トレーニングセミナーの有効性 (2013)
  • Author(s): 富川盛雅, 植村宗則, 神代竜一, 大内田研宙, 赤星朋比古, 家入里志, 大平猛, 田上和夫, 橋爪誠
  • Organizer: 第67回手術手技研究会
  • Place of Presentation: 札幌
  • Year and Date: 20130517-18
• [Presentation] 単孔式TEP法におけるXゲートと3D内視鏡の有用性 (2013)
  • Author(s): 富川盛雅, 長尾吉泰, 植村宗則, 吉田正樹, 堀淳一, 石井裕之, 大内田研宙, 赤星朋比古, 家入里志, 大平猛, 橋爪誠
  • Organizer: 第11回日本ヘルニア学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20130510-11
• [Presentation] ANALYSES OF OVER 800 TRAINEES ATTENDED AN INTEGRATED 2-DAY STANDARDIZED LAPAROSCOPIC SURGERY TRAINING COURSEATA SINGLE CENTER IN KYUSHU UNIVERSITY (2013)
  • Author(s): Tomikawa M, Uemura M, Nagao Y, Tsutsumi N, Kumashiro R, Souzaki R, Ohuchida K, Ieiri S, Ohdaira T, Hashizume M
  • Organizer: Society of American Gastrointestinal and Endoscopic Surgeons 2013 Scientific Session & Postgraduate Courses
  • Place of Presentation: Baltimore, MD, U.S.A
  • Year and Date: 20130417-20
• [Presentation] 低侵襲治療の安全性向上を目指した医用画像応用技術の現状とその将来展望 (2013)
  • Author(s): 富川盛雅, 神代竜一, 大内田研宙, 赤星朋比古, 前原喜彦, 橋爪誠
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20130411-13
• [Presentation] 内視鏡手術をより低侵襲に-低侵襲治療の研究開発とあたらしいデバイス- (2013)
  • Author(s): 富川盛雅
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20130411-13
• [Presentation] NG切断 (2013)
  • Author(s): 富川盛雅, 赤星朋比古, 池田哲夫, 橋爪誠
  • Organizer: 第7回内視鏡下肥満外科治療研究会
  • Place of Presentation: 福岡
  • Year and Date: 2013-11-27
• [Presentation] 硬性腹腔鏡と軟性内視鏡を併用した脾臓摘出術 (2013)
  • Author(s): 富川盛雅, 赤星朋比古, 神代竜一, 長尾吉泰, 前原喜彦, 橋爪誠
  • Organizer: 第8回LECS研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-12
• [Presentation] 内視鏡外科手術トレーニングセミナーにおける技術評価タスクの成績の解析 (2013)
  • Author(s): 富川盛雅, 植村宗則, 神代竜一, 豊田和孝, 森恩, 宗崎良太, 大内田研宙, 家入里志, 大平猛, 橋爪誠
  • Organizer: 第23回九州内視鏡下外科手術研究会
  • Place of Presentation: 鹿児島
  • Year and Date: 2013-08-24
• [Presentation] コンピューターが手術を変える
  • Author(s): 富川盛雅, 橋爪誠, 前原喜彦
  • Organizer: 第113回日本外科学会定期学術集会市民公開講座