2014 Fiscal Year Final Research Report
Spatial and component separations of the photoacoustic signal for achieving noninvasive blood glucose measurement
| Project/Area Number |
25560242
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 血糖値 / 非侵襲 / 光音響 / 近赤外光 / PAS / グルコース |
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| Outline of Final Research Achievements |
In order to measure the glucose concentration in a capillary bed based on photoacoustic spectroscopy, the techniques of separating unnecessary signal components generated from water and discriminating unnecessary signal components generated from the epidermis are required. The method of irradiating with the excitation light according to the absorption wavelength of water simultaneously with observation light was proposed to suppress the signal component originating in water. It was shown clearly that observation light intensity changes with irradiation of excitation light about 1% per 1% of glucose concentration. Therefore, a possibility that the water signal component in an observation signal could be estimated by irradiation of excitation light was indicated. In addition, it was confirmed that the glucose distribution of the depth about 5 mm from the surface could be identified by irradiating with the modulated observation light.
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| Free Research Field |
医用工学
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