The study and assessment of the exercise of cerebral ataxia Mouse in an enriched breeding environment fed with brain nourishing ingredients

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560268
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Fujita Health University
• Principal Investigator: BEPPU HIDEHIRO (別府秀彦) 藤田保健衛生大学, 藤田記念七栗研究所, 准教授 (30142582)
• Co-Investigator(Kenkyū-buntansha): SINZATO MASANORI 藤田保健衛生大学, 医療科学部, 准教授 (80148288)
• Co-Investigator(Renkei-kenkyūsha): MIZUTANI KENMEI 藤田保健衛生大学, 藤田記七栗研究所, 講師 (30351068) ; SONODA SHIGERU 藤田保健衛生大学, 医学部, 教授 (10197022) ; SIMPO KAN 藤田保健衛生大学, 藤田記七栗研究所, 教授 (10142580)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 小脳失調マウス / 強制運動 / 環境エンリッチメント / D型セリン / 運動歩行改善 / プルキンエ細胞変性 / 運動失調 / 脳栄養

Outline of Final Research Achievements

The application of EE concept to the gait exercise improvement of Cerebral Ataxia Mouse.At the same time, the effect of using D type Serin together with EE exercise, forced gait exercise and brain nourishing feeding on the amelioration of the lack of gait harmony, and reduction of tremor, cerebral Purukinje cells were investigated. As a result, clear exercise improvement can’t be seen, but improvement compared to forced training group is obvious.
For oral administration of D type Serine and EE exercise, equal results to forced exercise were obtained.

Free Research Field

リハビリテーション医学