Assessment of skeletal muscle function using membrane capacitance during aging

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560339
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Kyoto Gakuen University
• Principal Investigator: Kimura Misaka 京都学園大学, 健康医療学部, 教授 (90150573)
• Co-Investigator(Kenkyū-buntansha): YAMADA Yosuke 国立研究開発法人医薬基盤・健康・栄養研究所, 研究員 (60550118)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨格筋 / サルコペニア / 生体電気インピーダンス法 / 細胞膜 / 細胞内液

Outline of Final Research Achievements

Sarcopenia, age-related loss of skeletal muscle mass, strength, and function, is associated with impaired mobility, increased risk of falls, fractures, metabolic dysfunction and mortality. Many sarcopenia consensus definitions include low appendicular lean mass measured by dual energy x-ray absorptiometry (DXA); however, the association of DXA-measured lean mass with function is weak. Segmental bioelectrical impedance spectroscopy (S-BIS) provides a superior assessment of age-related muscle mass decline that is highly correlated with muscle functional loss. S-BIS measures accounted for ~85% of the age-related decrease in appendicular muscle power compared to only ~49% for DXA measures, and correlated strongly with leg muscle power independent of age. S-BIS measures including characteristic frequency, membrane capacitance, and phase angle, identified a predictive model that explained ~79% of inter-individual variance of leg muscle power.

Free Research Field

筋生理学