Mechanisms of exercise-induced muscle hypertrophy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560343
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: The University of Tokyo
• Principal Investigator: OGASAWARA Riki 東京大学, 総合文化研究科, 助教 (10634602)
• Co-Investigator(Renkei-kenkyūsha): FUJITA Satoshi 立命館大学, スポーツ健康科学部, 教授 (80451863) ; NAKAZATO Koichi 日本体育大学, 保健医療学部, 教授 (00307993) ; SATO Koji 立命館大学, スポーツ健康科学部, 助教 (20584022)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 運動 / 骨格筋 / 細胞外マトリックス / マトリックスメタロプロテアーゼ / 細胞接着分子 / インテグリン / 筋肥大 / シグナル伝達

Outline of Final Research Achievements

The purpose of the study was to investigate the effect of resistance exercise and aging on extracellular matrix (ECM) related proteins. Resistance exercise activates MMP-2 and MMP-9 during initial phase of resistance training but this response is attenuated with continuation of resistance training in rats. Resistance training increased β1-integrin (cell adhesion molecule) expression but not the other ECM proteins. Increases in integrins (α7- and β1-integrin) and reduced MMPs activities were also observed in older men compared with young men. These results suggest that integrins and MMPs play important role in the exercise-induced muscle hypertrophy.

Free Research Field

運動生理学