2013 Fiscal Year Final Research Report
Alternation of organ function in mice of jet-lag model
Project/Area Number |
25560426
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Basic / Social brain science
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Research Institution | Kyoto University |
Principal Investigator |
OKAMURA Hitoshi 京都大学, 薬学研究科(研究院), 教授 (60158813)
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Project Period (FY) |
2013-04-01 – 2014-03-31
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Keywords | 脳とリズム |
Research Abstract |
Timed activities such as eating and sleeping are crucial for a comfortable social life and healthy living. As the living environment changes rapidly, and the numbers of around-the-clock facilities and people staying awake all night increase the convenience of consumers and the productivity of industries, the biological system to regulate our internal rhythms is being compromised. From screening the knockout of a variety of genes expressed in the SCN, here we identified the mice which do not show jet-lag even when they exposed suddenly to the 8-hour phase advance. We identified that the local circuits of vasopressin/V1aV1b-receptors in the SCN are crucial for jet-lag formation. From the analysis of chronic jet lag conditions, we want to clarify the mechanism of a life-style related disease evoked by chronic jet-lag.
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[Journal Article] Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag2013
Author(s)
Yamaguchi Y, Suzuki T, Mizoro Y, Kori H, Okada K, Chen Y, Fustin JM, Yamazaki F, Mizuguchi N, Zhang J, Dong X, Tsujimoto G, Okuno Y, Doi M, Okamura H
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Journal Title
Science
Volume: 342
Pages: 85-90
Peer Reviewed
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[Journal Article] RNA-methylation- dependent RNA processing controls the speed of the circadian clock2013
Author(s)
Fustin JM, Doi M, Yamaguchi Y, Hayashi H, Nishimura S, Yoshida M, Isagawa T, Suimye-Morioka M, Kakeya H, Manabe I, Okamura H
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Journal Title
Cell
Volume: 155
Pages: 793-806
Peer Reviewed
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[Presentation]2014
Author(s)
岡村均
Organizer
第51回日本臨床分子医学会
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
20140411-12