The multidimensional assesment system of developmental disorder model in mice

2014 Fiscal Year Final Research Report

• Project/Area Number: 25590213
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental psychology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YAMADA Ikuko 独立行政法人理化学研究所, バイオリソースセンター, 開発技師 (60568723)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 発達障害 / マウス / 行動テストバッテリー / 社会行動 / 学習障害 / 注意欠陥・多動性障害

Outline of Final Research Achievements

In this study, I tried to establish a multidimensional-assessment system of behavioral phenotypes of mutant mice. In order to validate this system, an ENU mutant mouse B6- Grin1Rgsc174 that is known as an animal model of attention-deficit hyperactivity disorder was tested in this pipeline. The data which collected in the test pipeline were statistically stable and had less variation among subjects. Moreover, common behavioral characteristics widely observed in developmental disorders such as hyper activity, decrease of social approach, and learning disorder were observed also in B6- Grin1Rgsc174 mutant.
These results indicate that the test battery which was established in this study is capable of evaluating the detected characteristic behaviors of the models of developmental disorders with high sensitivity.

Free Research Field

行動科学