2013 Fiscal Year Final Research Report

Highly-controlled asymmetric environment using chiral metal nanoclusters

Research Project

Project/Area Number	25620026
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Organic chemistry
Research Institution	The University of Tokyo
Principal Investigator	KOBAYASHI Shu 東京大学, 理学(系)研究科(研究院), 教授 (50195781)
Project Period (FY)	2013-04-01 – 2014-03-31
Keywords	反応有機化学 / 触媒
Research Abstract	We attained the construction of highly-controlled asymmetric environment utilizing chiral metal nanocluster catalysts we originally developed. Asymmetric 1,4-addition reactions of aromatic boronic acids with nitroolefins were developed and it became clear that a chiral diene with amide moiety could give high enantioselectivity. Furthermore, three reactions (alcohol oxidation with molecular oxygen, formation of unsaturated carbon-carbon bond, and asymmetric 1,4-addition reactions of arylboronic acids with unsaturated carbonyl compounds) were accumulated and these reactions were found to proceed continuously with high selectivities by sequential addition of catalysts and substrates. Analysis of chiral nanocluster catalysts was also performed.