Functionalization of oxidized small molecules using cooperative asymmetric catalysts

2014 Fiscal Year Final Research Report

• Project/Area Number: 25620075
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Chiba University
• Principal Investigator: ARAI TAKAYOSHI 千葉大学, 理学(系)研究科(研究院), 教授 (80272483)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 触媒 / 不斉合成 / 協奏機能 / 金属 / プロトン / 低分子量化合物 / カルボン酸 / ニトロ基

Outline of Final Research Achievements

Originally developed Bis(imidazolidine)pyridine (PyBidine)-metal catalysts enabled various kinds of asymmetric reactions using oxidized small substrates. For the examples, PyBidine-Ni complex smoothly catalyzed asymmetric iodolactonization, nitro-Mannich reaction, and N,O-acetal formation. Chiral secondary amine-Cu complex, bis(oxazolidine)pyridine (PyBodine)-metal complex, and imidazolidine-consisting pincer complex were also prepared for showing the cooperative effect of metal-Lewis acids with proton. Based on the metal-carboxylate formation in the PyBidine-metal catalysis, a new tri-zinc complex was also developed for the asymmetric iodolactonization. Using these concert catalysts, intermolecular reaction using carbon dioxide and acetic acid was studied.

Free Research Field

有機合成化学