Design and synthesis of a molecular providing physical perturbation on living cell

2014 Fiscal Year Final Research Report

• Project/Area Number: 25620119
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: Fukuoka University
• Principal Investigator: SHIOJI Kosei 福岡大学, 理学部, 准教授 (80291839)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 光異性化 / アゾベンゼン / 細胞 / ホスホニウム塩

Outline of Final Research Achievements

Photomechanical effects of photochromic materials, which induce mechanical motions upon photoirradiation, have attracted a great deal of attention in recent years. Azo compounds are famous as dye and known for its photoisomerization by irradiation of UV light. We have synthesized an azo compound, having triphenylphosphonium salt to improve the subcellular localization ability, BODIPY as a fluorophore. The azo compound photoisomerized by visible light only. Furthermore, we observed the changes in cell morphological by effect of photoirradiation when introducing the compound into living cells.

Free Research Field

有機化学