Development of hyperpolarized molecular probes toward in vivo redox analysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25620135
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: The University of Tokyo (2014); Kyushu University (2013)
• Principal Investigator: NONAKA Hiroshi 東京大学, 工学(系)研究科(研究院), 講師 (80579269)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 核磁気共鳴 / 核偏極 / 酸化還元 / 分子プローブ

Outline of Final Research Achievements

In this research, we have attempted to develop new hyperpolarized chemical probes toward the redox analysis in vivo. To this end, we have utilized the magnetic resonance analysis and the hyperpolarization technique. The hyperpolarization is a highly potential method to enhance magnetic resonance signals dramatically. However, the hyperpolarization method has a shortcoming, which is the short lifetime of the polarized spin state in solution. To resolve this problem, first we have explored the structure having long hyperpolarization lifetime. We have successfully explored the potent structures. Then we have found the mechanisms to induce the large chemical shift change for sensing of redox balance. We expect these findings would be valuable to develop redox-responsible hyperpolarized sensors.

Free Research Field

化学生物学