Elucidation of anticancer activity of organic/metallic hybrid polymer

2014 Fiscal Year Final Research Report

• Project/Area Number: 25620166
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Organic and hybrid materials
• Research Institution: National Institute for Materials Science
• Principal Investigator: HIGUCHI Masayoshi 独立行政法人物質・材料研究機構, 高分子材料ユニット, グループリーダー (80306852)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 有機／金属ハイブリッドポリマー / 抗がん特性

Outline of Final Research Achievements

We found organic-metallic hybrid polymer binds with DNA chains strongly due to the ionic interaction before. In this project I tried to reveal (1) the detailed interaction of organic-metallic hybrid polymer with DNA chains and (2) anticancer activity of organic-metallic hybrid polymer. The achievements are following.

We successfully prepared organic-metallic hybrid polymers with different chain length and investigated the cytotoxicity to cancer cells. Interestingly, the organic-metallic hybrid polymer with the stronger binding affinity to DNA showed the higher anticancer activity.

Free Research Field

高分子科学