Development of Cardiac Patch of Silk Fibroin Controlled The Bioabsorbable Property

2015 Fiscal Year Final Research Report

• Project/Area Number: 25620169
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer/Textile materials
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Asakura Tetsuo 東京農工大学, 工学(系)研究科(研究院), 名誉教授 (30139208)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 高分子材料 / 医療用パッチ / 絹 / ポリウレタン / エレクトロスピニング / トランスジェニック高機能化絹

Outline of Final Research Achievements

Several kinds of functional silk fibroins containing the amino acid sequences suitable for biomaterials were produced by transgenic silkworms. The composite materials with these silk fibroins and segmented polyurethane were prepared with electrospinning technique. The cardiac patch and artificial vascular grafts with very small diameter were developed. Animal implantation experiments using these composite materials showed these materials have excellent operability for implantation and excellent properties for the purpose.

Free Research Field

化学　材料化学　高分子・繊維材料