Development of controlling method of microcapsule disintegration for regenerative medicine by underwater shock waves

2014 Fiscal Year Final Research Report

• Project/Area Number: 25630054
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: Kyushu Institute of Technology
• Principal Investigator: TAMAGAWA Masaaki 九州工業大学, 生命体工学研究科(研究院), 教授 (80227264)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 水中衝撃波 / マイクロカプセル / 気泡 / 再生医療

Outline of Final Research Achievements

In this investigation, to make structure of 3D living tissue in vitro or in vivo, special microcapsules composed of a gas bubble, cells, and cultivation liquid were developed, which can be disintegrated and make stimulus to internal cells by controlling the strength of shock waves. It was concluded that (1) the microjet induced disintegration occurred when gas/liquid ratio was 30-40% by observing deformation process of a bubble in a capsule under microscopy, (2) the oscillation amplitude of a bubble increases when the gas/liquid ratio was small by analyzing special simplified mathematical model, and it corresponded to the observation results.

Free Research Field

生体流体工学