2014 Fiscal Year Final Research Report
Movement of blood cell components measured by Optical Coherence Tomography
| Project/Area Number |
25630057
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Fluid engineering
|
|---|
| Research Institution | Kansai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SEKI Junji 関西大学, 先端科学技術推進機構, 非常勤研究員 (20163082)
MAKINO Masato 山形大学大学院, 理工学研究科, 助教 (10649172)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 光コヒーレンス断層法 / 血球 |
|---|
| Outline of Final Research Achievements |
This study was aimed to develop an optical coherence tomography (OCT) system which can measure the spatial distribution of blood cell components in microvessels. First we developed a time-domain OCT system using a super luminescent diode (SLD), the spatial resolution of which was about 12 um in water. Polystyrene particles with 10 um diameter floating in a tube with inner diameter less than 1 mm could be observed by this OCT system. Next, the OCT system was improved to a frequency domain OCT by replacing the light source with a swept source laser with broader band width and high repetition rate, resulting in a higher spatial resolution as well as a higher-speed tomography. This improvement enabled the measurement of positions of particles flowing through sub-millimeter tubes. Further the segregation behavior of blood cell components was numerically simulated using a two-dimensional model, and its mechanism was examined by comparing the results with experimental observations.
|
| Free Research Field |
生理流体力学
|
