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2013 Fiscal Year Final Research Report

Challenge of On-chip Precise Enucleation of Oocyte Using 3D 6DOF Manipulation

Research Project

  • PDF
Project/Area Number 25630090
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionNagoya University

Principal Investigator

ARAI Fumihito  名古屋大学, 工学(系)研究科(研究院), 教授 (90221051)

Co-Investigator(Kenkyū-buntansha) ICHIKAWA Akihiko  名城大学, 理工学部, 准教授 (20377823)
Project Period (FY) 2013-04-01 – 2014-03-31
KeywordsMicro-nano devices / Microrobot / Micromachine / Manipulation / Oocyte
Research Abstract

At present, enucleation of oocyte is performed using mechanical micromanipulators. High throughput, precise, and efficient enucleation is highly demanded. In this research, we challenged basic technologies of position and orientation control of oocyte as well as continuous and precise enucleation on a microfluidic chip. We proposed position and orientation control of oocyte by using noncontact manipulation of magnetically driven microrobots. We developed a magnetically driven microrobot with microgripper. By using microneedle, we succeeded in making a small hall at the zona pellucida, and enucleated by pushing the oocyte with the microgripper. For continuous and precise enucleation on a chip, we proposed loading mechanism, which can load the oocyte one by one by using gravitational force. Effectiveness of our method was shown by experiments.

  • Research Products

    (6 results)

All 2014 2013 Other

All Journal Article (1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] On-chip enucleation of Oocyte by untethered microrobots2014

    • Author(s)
      Akihiko Ichikawa, Shinya Sakuma, Masakuni Sugita, Tatsuro Shoda, Takahiro Tamakoshi, Satoshi Akagi, Fumihito Arai
    • Journal Title

      Journal of Micromechanics and Microengineering

      Volume: (in press)

  • [Presentation] 把持機構を有する磁気駆動オンチップロボットとマイクロナイフによる卵細胞の除核2014

    • Author(s)
      市川明彦, 佐久間臣耶, 正田達郎, 玉腰貴浩, 新井史人, 赤木悟史
    • Organizer
      第31回日本ロボット学会学術講演会
    • Year and Date
      20140900
  • [Presentation] Untethered Micro-Robot with Gripping Mechanism for On-Chip Cell Surgery Utilizing Outer Magnetic Force2014

    • Author(s)
      Akihiko Ichikawa, Shinya Sakuma, Fumihito Arai and S. Akagi
    • Organizer
      IEEE International Conference on Robotics and Automation (ICRA2014)
    • Year and Date
      20140500
  • [Presentation] ON-CHIP ENUCLEATION OF OOCYTE USING UNTETHERD MICRO-ROBOT WITH GRIPPING MECHANISM2013

    • Author(s)
      Akihiko Ichikawa, Shinya Sakuma, Tatsuro Shoda, Fumihito Arai and S. Akagi
    • Organizer
      2013 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2013)
    • Year and Date
      20131100
  • [Presentation] ON-CHIP ENUCLEATION OF OOCYTE USING UNTETHERD MICROROBOT WITH GRIPPING MECHANISM2013

    • Author(s)
      Akihiko Ichikawa, Shinya Sakuma, Tatsuro Shoda, Fumihito Arai and S. Akagi
    • Organizer
      The 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (micro-TAS2013)
    • Year and Date
      20131000
  • [Remarks] 新井研究室名古屋大学大学院工学研究科マイクロ・ナノシステム工学専攻(機械理工学専攻)

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/

URL: 

Published: 2015-06-25  

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