2013 Fiscal Year Final Research Report
Challenge of On-chip Precise Enucleation of Oocyte Using 3D 6DOF Manipulation
| Project/Area Number |
25630090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Nagoya University |
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Principal Investigator |
ARAI Fumihito 名古屋大学, 工学(系)研究科(研究院), 教授 (90221051)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Akihiko 名城大学, 理工学部, 准教授 (20377823)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | Micro-nano devices / Microrobot / Micromachine / Manipulation / Oocyte |
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| Research Abstract |
At present, enucleation of oocyte is performed using mechanical micromanipulators. High throughput, precise, and efficient enucleation is highly demanded. In this research, we challenged basic technologies of position and orientation control of oocyte as well as continuous and precise enucleation on a microfluidic chip. We proposed position and orientation control of oocyte by using noncontact manipulation of magnetically driven microrobots. We developed a magnetically driven microrobot with microgripper. By using microneedle, we succeeded in making a small hall at the zona pellucida, and enucleated by pushing the oocyte with the microgripper. For continuous and precise enucleation on a chip, we proposed loading mechanism, which can load the oocyte one by one by using gravitational force. Effectiveness of our method was shown by experiments.
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