2015 Fiscal Year Final Research Report
Formation of artificial nano-cells for in-situ TEM observation of material reaction in the water
| Project/Area Number |
25630269
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical properties of metals/Metal-base materials
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | バイオマテリアル / 水 / TEM / リポソーム / DPPC / リン脂質二重層膜 / コレステロール |
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| Outline of Final Research Achievements |
Liposome reinforced by adding cholesterol was synthesized using the dipalmitoylphosphatidylcholine (DPPC). Phase stability of the phospholipid bilayers was examined by FTIR spectroscopy. The reinforced liposomes filled with ultrapure water or physiological saline were observed by the conventional TEM equipped with a mass spectrometer. It was confirmed that the liposomes filled with water or saline solution were stable in the vacuum at room temperature. However、 during electron irradiation、 water molecules escaped gradually、 and a single crystal of rock salt precipitated in the liposome. Similar phenomenon was also observed in the case of cesium iodide solution.
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| Free Research Field |
ナノ材料
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