2014 Fiscal Year Final Research Report
Analysis of signal dynamics mediated by AMPK subfamily in synapse maturation
| Project/Area Number |
25640009
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 分子細胞神経科学 / アクティブゾーン |
|---|
| Outline of Final Research Achievements |
Accumulating evidence suggests that serine /threonine kinase AMPK subfamily regulate neuronal polarization such as axon/dendrite formation. Here, we show that 1) MARK and AMPK1 are biochemically localized and expressed in the nerve terminals, in particular synaptic vesicles and active zone fractions; 2) phosphorylation of CAST regulates release of neurotransmitter from the active zone; and 3) SAD family may be involved in cell death. These results suggest that AMPK family member regulate not only neuronal polarization but also neurotransmitter release from the nerve terminals.
|
| Free Research Field |
神経生化学
|
