Activin-A is a cell proliferation factor of the GABAergic neuron progenitors in the mouse neocortex

2014 Fiscal Year Final Research Report

• Project/Area Number: 25640023
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kumamoto University
• Principal Investigator: TAMAMAKI Nobuaki 熊本大学, 大学院生命科学研究部(医), 教授 (20155253)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: Activin A

Outline of Final Research Achievements

Neocortex is composed of 80% of excitatory neurons, and 20% of inhibitory neurons. The ratio of the neocortical neurons are determined when the cerebral neocortex is formed. Thus when the two types of neurons are produced, it is important to detect the ratio between the two types of neurons. To do this, the two types of neurons must detect the total number of each neurons. In other words, the production of neurons will regulated by molecules that released from the two type of neocortical neurons. According to our speculation, one of the molecule is Activin-A.

Free Research Field

神経科学