Effect of Mg-L-threonate on alpha synuclein Tg mice

2014 Fiscal Year Final Research Report

• Project/Area Number: 25640028
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Shinshu University
• Principal Investigator: OYANAGI Kiyomitsu 信州大学, 医学部, 特任教授 (00134958)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Emi (香山 絵美) 信州大学, 医学部, 研究員 (80623686) ; FUJITA Masayo 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (90415539)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: パーキンソン病 / アルファシヌクレイン遺伝子組換えマウス / マグネシウム / マグネシウム-L-スレオネート

Outline of Final Research Achievements

Magnesium-L-threonate (Mg-L-Th: It had been reported that the oral intake of Mg-L-Th increased the concentration of Mg in the cerebrospinal fluid by 10 to 20%. Mg-L-Th was purchased from two companies (A and B).) was administered to the alpha-synuclein transgenic (aSyn tg) mice, which are considered to be a model of Parkinson disease, and the wild type (WT) mice. Gait of aSyn tg mice, such as width of forefoot and hind foot, was not improved by Mg-L-Th administration. In addition, frequency of jumping to the cage wall of aSyn tg mice was not decreased. But the concentration of dopamine in the neostriatum, which was lower in aSyn tg mice than WT mice, was increased significantly in aSyn tg mice by Mg-L-Th from A company.

Free Research Field

神経病理学