Mechanisms of brain formation regulated by birth

2014 Fiscal Year Final Research Report

• Project/Area Number: 25640032
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kanazawa University
• Principal Investigator: KAWASAKI Hiroshi 金沢大学, 脳・肝インターフェイスメディシン研究センター, 教授 (50303904)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 神経細胞成熟

Outline of Final Research Achievements

Using the cerebral cortex of embryonic and neonatal mice, microarray experiments were performed to identify the molecules whose expression levels changed before and after birth. Using in utero electroporation, loss- and gain-of-function studies were carried out, and we identified molecules that negatively regulated dendritic maturation. Furthermore, we found that the migration of immature neurons was also affected, suggesting that dendritic maturation should occur appropriate time point during development. Our results uncovered a novel regulatory mechanisms of neuronal maturation soon after birth.

Free Research Field

脳神経医学