2015 Fiscal Year Final Research Report
Modification of neuronal identity specification in the developing brain
| Project/Area Number |
25640039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ARAMAKI MICHIHIKO 慶應義塾大学, 医学部, 助教 (20338099)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 大脳新皮質 / 神経細胞 / 層特異性 / 転写因子 |
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| Outline of Final Research Achievements |
In this study, we found that overexpression of a certain gene could modify the neuronal identity in the developing cerebral neocortex. In the upper cortical plate neurons, a mutually repressive mechanism exists between two kinds of transcription factors, Brn2 and Rorb, and the established expression of Brn1/2 and Rorb specifies those neurons into layer 2-3 and layer 4, respectively, during cortical plate maturation.
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| Free Research Field |
発生神経生物学
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