Role of CD274 in cancer stem cell of cholangicarcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 25640073
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: SHIINA Masaaki 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 (50455820)
• Co-Investigator(Renkei-kenkyūsha): TAMAI Keiichi 宮城県立がんセンター研究所, 上席主任研究員 (40509262) ; SUGAMURA Kazuo 宮城県立がんセンター研究所, 特任部長 (20117360)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: がん幹細胞

Outline of Final Research Achievements

We demonstrate that CD274-low population in cholnagiocarcinoma cells have high tumorigenicity, high ALDH activity, low ROS production. Furthermore, CD274 low group in cholangiocarcinoma patients shows poorer prognosis when compared with the CD274 high group. These data strongly suggest that CD274 plays pivotal roles in ca cer stem cells of cholangiocarcinoma.

Free Research Field

消化器病学