Establishment of local and switchable innate immune activation by novel nucleic acid adjuvant

2014 Fiscal Year Final Research Report

• Project/Area Number: 25640084
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics
• Research Institution: Hokkaido University
• Principal Investigator: TAKAOKA Akinori 北海道大学, 遺伝子病制御研究所, 教授 (30323611)
• Co-Investigator(Renkei-kenkyūsha): SATO Seiichi 北海道大学, 遺伝子病制御研究所, 助教 (60459724) ; KAMEYAMA Takeshi 北海道大学, 遺伝子病制御研究所, 助教 (40569505)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 自然免疫 / 核酸 / アジュバント

Outline of Final Research Achievements

Adjuvant is an important component for effective vaccination and antitumor therapy. Establishment of local and switchable adjuvant is considered to be an efficient strategy to reduce side effects and efficiently activate innate immune responses. The purpose of this study is the establishment of a novel nucleic acid adjuvant that can trigger the activation of innate immune system in response to X-ray irradiation. In this study, type-C CpG ligands contained with cystamine-modified cytosine were used and showed its structural change by X-ray irradiation, albeit their low efficiency. These results showed these ligands could be a switchable activator and further investigation will be needed to improve their efficiency.

Free Research Field

免疫学