2015 Fiscal Year Final Research Report
Elucidation of regulatory mechanism of DNA repair factor to overcome intractable breast cancer
Project/Area Number |
25640086
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Tumor therapeutics
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Research Institution | Tohoku University |
Principal Investigator |
Chiba Natsuko 東北大学, 加齢医学研究所, 教授 (50361192)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | BRCA1 |
Outline of Final Research Achievements |
BRCA1 is an important breast and ovarian cancer susceptibility gene. Hereditary cancers with BRCA1 mutations and sporadic c ancers with lower BRCA1 expression are sensitive to platinating agent and PARP inhibitor. We identified a novel BRCA1-interacting protein (BIP) and found that overexpression of BIP causes reduction of BRCA1 and BARD1, which is also BRCA1-interacting protein. Interestingly, the expression level of BRCA1 and BIP show a negative correlation in several cancer cell lines. These suggest that the expression level of BIP is a candidate of biomarkers or molecular targets of cancer chemotherapy.
|
Free Research Field |
腫瘍生物学
|