Elucidation of regulatory mechanism of DNA repair factor to overcome intractable breast cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25640086
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics
• Research Institution: Tohoku University
• Principal Investigator: Chiba Natsuko 東北大学, 加齢医学研究所, 教授 (50361192)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: BRCA1

Outline of Final Research Achievements

BRCA1 is an important breast and ovarian cancer susceptibility gene. Hereditary cancers with BRCA1 mutations and sporadic c ancers with lower BRCA1 expression are sensitive to platinating agent and PARP inhibitor. We identified a novel BRCA1-interacting protein (BIP) and found that overexpression of BIP causes reduction of BRCA1 and BARD1, which is also BRCA1-interacting protein. Interestingly, the expression level of BRCA1 and BIP show a negative correlation in several cancer cell lines. These suggest that the expression level of BIP is a candidate of biomarkers or molecular targets of cancer chemotherapy.

Free Research Field

腫瘍生物学