2014 Fiscal Year Final Research Report
Effects of thiacalixarene derivatives on the proliferation and the cell cycle distribution of leukemia cell line
| Project/Area Number |
25640087
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | チアカリックスアレーン / 抗がん剤 / 細胞周期 |
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| Outline of Final Research Achievements |
Thiacalixarenes, cyclic oligomers of p-alkylphenol bridged by sulfur atoms, are supramolucules known to have potent coordinating ability to metal ions. We have found so far that thiacalix[6]arene hexasulfate (TC6AHS) affects the distribution of cell cycle in leukemia cell lines. In this study, we aimed to elucidate the effect of newly-synthesized TC6AHS derivatives on the cell cycle progression and the proliferation. Thiacalix[6] arene (TC6A) was found to be induced the arrest at the G1 phase, while TC6AHS arrested at the G2/M phase. Moreover, TC6A exihibited a potent anti-proliferative activity against Jurkat cells, as compared to TC6AHS.
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| Free Research Field |
生化学
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