Structure determination of human membrane transporters

2014 Fiscal Year Final Research Report

• Project/Area Number: 25650023
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Structural biochemistry
• Research Institution: Kyoto University
• Principal Investigator: SHIMAMURA Tatsuro 京都大学, 医学(系)研究科(研究院), 講師 (90391979)
• Co-Investigator(Kenkyū-buntansha): NOMURA Morimichi 京都大学, 大学院医学研究科, 助教 (10314246)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Yoshiki 京都大学, 大学院医学研究科, 研究員 (10632333) ; OGASAWARA Satoshi 京都大学, 大学院医学研究科, 研究員 (30546685) ; ARAKAWA Takatoshi 京都大学, 大学院医学研究科, 研究員 (30523766)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 膜輸送体 / 結晶構造解析 / 創薬

Outline of Final Research Achievements

Membrane transporters are drug targets because they are important causes of diseases. Therefore, the structural information of human membrane transporters is very useful for the rational design of new drugs. However, it is difficult to determine the crystal structure of membrane transporters because of their instabilities. We tried to crystallize mammalian transporters using the recently developed methods for the membrane protein crystallization and succeeded to crystallize some of the membrane transporters.

Free Research Field

構造生物学