2015 Fiscal Year Final Research Report
Analysis of growth-promoting mechanism of neural stem cells with tissue kallikrein.
| Project/Area Number |
25650039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo University of Science, Yamaguchi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 組織性カリクレイン / 神経幹細胞 |
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| Outline of Final Research Achievements |
This study aimed to elucidate the growth-promoting mechanism of action mechanism of neural stem cells with tissue kallikrein. In this study, We found that kallikrein inhibited NF-kappa B pathway of neural stem cells. As a result of examining the pathways that activate NF-kappa B pathway, we found that kallikrein cleaved the IL-1 type I receptor. Activation of the NF-κB pathway has been reported to promote the differentiation of neural stem cells. These results suggests that suppressing the differentiation of neural stem cells by kallikrein increases the apparent cell growth rate in neural stem cells.
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| Free Research Field |
生化学
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