2014 Fiscal Year Final Research Report
The molecular mechanisms of cell-to-cell communication by a cleaved endoplasmic reticulum stress transducer
| Project/Area Number |
25650069
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 細胞内情報伝達機構 / 小胞体 / ヘッジホッグシグナル / 細胞増殖 / 軟骨 / 癌 |
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| Outline of Final Research Achievements |
The endoplasmic reticulum (ER) stress transducer BBF2H7 is an ER-resident transmembrane protein. In response to ER stress, it is processed at the transmembrane region to generate a cytoplasmic N-terminus and luminal c-terminus. We found that BBF2H7 C-terminus is secreted into extracellular space as a signaling molecule for cell-to-cell communication. The secreted BBF2H7 c-terminus directly binds to both hedgehog and its receptor Patched-1, followed by activation of hedgehog signaling, resulting in promoting the proliferation of neighboring cells. The effects of BBF2H7 C-terminus on cell growth are observed in developing chondrocytes and tumor cells such as glioblastomas and breast cancers.
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| Free Research Field |
医化学
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