2014 Fiscal Year Final Research Report
Comprehensive understanding of organelle division and multiplication on bases of elucidation of dividing machinery of microbody
| Project/Area Number |
25650101
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Rikkyo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | マイクロボディ / ペルオキシソーム / 膜系オルガネラ / 単膜系オルガネラ / 複膜系オルガネラ / 分裂マシン / ダイナミン |
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| Outline of Final Research Achievements |
The double-membrane-bounded and the single-membrane-bounded organelles are required to fulfill the functions of eukaryotic cells. Cyanidioschyzon merolae cells contain a minimum set of essential organelles and their cell cycles are synchronized by light and dark cycles. We found the dividing machineries (MD and PD) in double-membrane-bounded mitochondria and plastids.
In this study, we have found using omics research that a single-membrane-bounded organelle, microbody (peroxisome), divides using a complex of outer ring (POD) containing dynamin (similar to mitochondrial dynamin) and inner ring composed of fine filaments, and proposed a molecular model of microbody machinery. Finally we compared POD, MD and PD.
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| Free Research Field |
細胞科学
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