Identification of a secreted factor that regulates nitrogen metabolism in fission yeast

2014 Fiscal Year Final Research Report

• Project/Area Number: 25660070
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied microbiology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YASHIRODA Yoko 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (60360658)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 分裂酵母 / 代謝 / 細胞間情報交換

Outline of Final Research Achievements

We identified a hydroxy fatty acid and an acetoxy-fatty acid that are secreted from fission yeast. In the presence of preferred a nitrogen source like ammonia, yeast prevent permeases to uptake non-preferred nitrogen sources like amino acids. Our study reveals that in the presence of those fatty acids, yeast seems to uptake non-preferred nitrogen sources even in the presence of much ammonia in the media. This result suggests that there exists a novel compound-mediated cell-cell communication system for nitrogen metabolism in fission yeast.

Free Research Field

分子生物学、遺伝学