Metabolic design of higher plants for useful material production by metabolic engineering

2015 Fiscal Year Final Research Report

• Project/Area Number: 25660084
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied biochemistry
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Hirai Masami 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームリーダー (90415274)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 数理モデル / 代謝 / 高等植物 / メタボローム

Outline of Final Research Achievements

Aiming at designing metabolism of higher plants for metabolic engineering and generating crops with enhanced useful material production, I established a method for genome-scale mathematical modeling of metabolism in Arabidopsis thaliana. Differential equations in a model were symbolically established based only on a metabolic map. Then parameters in the model were estimated by using time-series metabolome data which were obtained from metabolically perturbed A. thaliana. The established model were successfully used for system analyses.

Free Research Field

植物科学