• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Peptide coupling of unprotected amino acids with an active ester support under biphasic condition

Research Project

  • PDF
Project/Area Number 25660087
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bioorganic chemistry
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

KITANO Yoshikazu  東京農工大学, (連合)農学研究科(研究院), 准教授 (10302910)

Co-Investigator(Renkei-kenkyūsha) CHIBA Kazuhiro  東京農工大学, 大学院農学研究院, 教授 (20227325)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsペプチド合成 / 無保護アミノ酸
Outline of Final Research Achievements

Peptide coupling of unprotected amino acids was examined with an active ester support under biphasic condition. At first, an active ester support which has polyalkoxyphenol ethers and N-hydroxyimide moieties was synthesized. The desired coupling reaction of unprotected amino acids proceeded effectively by using the synthesized active ester compound. In addition, the reusability of the ester active support was verified after using the coupling reaction. It was suggested that this method could be applied to the continuous peptide coupling of unprotected amino acids.

Free Research Field

生物有機化学

URL: 

Published: 2016-09-02  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi