Potential of immune modulatory effect of dietary fiber through goblet cell proliferation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25660101
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Shizuoka University
• Principal Investigator: MORITA Tatsuya 静岡大学, (連合)農学研究科(研究院), 教授 (90332692)
• Co-Investigator(Kenkyū-buntansha): HINO Shingo 静岡大学, (連合)農学研究科(研究院), 助教 (70547025)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 食物繊維 / 杯細胞

Outline of Final Research Achievements

First, rats were fed a semipurified diet or a elemental diet with or without dietary fiber. After feeding, intestinal permeability and the number of goblet cells in the small intestine was examined. Ingestion of dietary fiber increased the number of small intestinal goblet cell number and the intestinal permeability. Second, we found that ingestion of dietary fiber increased cytokine expression such as TNF-a, IFN-g and IL-17 in the small intestine. These data suggested that ingestion of dietary fiber modulate intestinal permeability and intestinal immune systems. However, to clarify the interaction between the number of goblet cells and these phenomina, we need futher experiments.

Free Research Field

栄養化学