Exploring the evolution of Helicobacter pylori in deep-sea: a comprehensive analysis of ancestral microbes-host interactions.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25660146
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Aquatic bioproduction science
• Research Institution: Kyoto University (2014-2015); Hokkaido University (2013)
• Principal Investigator: Nakagawa Satoshi 京都大学, (連合)農学研究科(研究院), 准教授 (70435832)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 深海底熱水活動域

Outline of Final Research Achievements

The main objective of this study is to reveal the molecular mechanisms underlying the symbiosis between invertebrates and their epibionts in deep-sea hydrothermal vent environments. We especially have focused on the squat crab which is endemic to Japanese deep-sea hydrothermal fields (approximately 1000m in depth). The crab, on its setae, harbors sulfur-oxidizing symbionts belonging to Epsilonproteobacteria (including Helicobacter pylori) or Gammaproteobacteria. Effects of environmental fluctuations on the transcriptome and metabolome were examined. The molecular data were compared with corresponding data from host-endosymbiont symbiosis in deep-sea or host-pathogen interactions.

Free Research Field

微生物生態学