Sponge-metabolomics for the discovery of new bioactive natural products

2014 Fiscal Year Final Research Report

• Project/Area Number: 25660163
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Aquatic life science
• Research Institution: The University of Tokyo
• Principal Investigator: TAKADA Kentaro 東京大学, 農学生命科学研究科, 助教 (90455353)
• Co-Investigator(Renkei-kenkyūsha): OKUDA Shujiro 新潟大学, 大学院医歯学総合研究科, 准教授 (00512310) ; ISE Yuji 名古屋大学, 大学院理学研究科, 特任助教 (20535108)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 海洋天然物 / メタボロミクス / 生物活性物質

Outline of Final Research Achievements

Marine sponges are an important source of structurally diverse and biologically active natural products, several of which have inspired the development of therapeutic agents. In this project, 1500 extracts of marine sponges collected in Japanese shallow-sea or deep-sea were analyzed by LC-MS followed by cluster analyses to reveal their chemical profiles. Based on the chemical profiles, we isolated three cytotoxic peptides and three cytotoxic glycolipids from two different marine sponges. Their structures were determined by a combination of chemical methods and spectroscopic data analyses.

Free Research Field

海洋天然物化学