2015 Fiscal Year Final Research Report
Epigenetic regulation of placentation
| Project/Area Number |
25660209
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 着床 / 胎盤形成 / 共通遺伝子発現 / トロホブラスト細胞 / 細胞分化誘導 / 国際研究者交流 |
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| Outline of Final Research Achievements |
To study how placental formation is epigenetically regulated, differences between invasive and non-invasive placentation were studied. In invasive placentation, a transcription factor Cited2 in rat trophoblast Rcho cells was down-regulated, resulting in the differentiation of spongiotrophoblast, instead of trophoblast giant cells. In non-invasive trophoblast, trophoblasts in elongated conceptuses used mechanisms associated with lymphocyte homing, epithelial-mesenchymal transition (EMT) and endogenous retroviruses for their fusogenic activity, all of which have been published.
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| Free Research Field |
動物資源・繁殖学
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