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2014 Fiscal Year Final Research Report

Study on the mechanisms of corpus luteum disappearance during luteolysis

Research Project

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Project/Area Number 25660212
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Animal production science
Research InstitutionOkayama University

Principal Investigator

OKUDA Kiyoshi  岡山大学, その他の研究科, 教授 (40177168)

Co-Investigator(Kenkyū-buntansha) INOUE Naoko  名古屋大学, 農学部, 特任助教 (90377789)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywords構造的黄体退行 / 黄体細胞 / リンパ管 / MMPs
Outline of Final Research Achievements

In mammals, corpus luteum (CL), formed after ovulation on ovary, is endocrine organ which repeats formation and regression (luteolysis). This study revealed that luteolysis mechanism involve outflow of luteal cells from the CL to lymphatic vessels. We suggested that matrix metalloproteinases (MMPs), which degrade extracellular matrix, secreted by luteal cells have important roles to achieve outflow of luteal cells, and showed that MMPs expression in luteal cells is regulated by PGF2α and IFNG inducing luteolysis.

Free Research Field

生殖生理学

URL: 

Published: 2016-09-02  

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