Challenge for enhancement of antimicrobial peptides expression responsible for innate immune functions in the gut of chicks

2015 Fiscal Year Final Research Report

• Project/Area Number: 25660213
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Animal production science
• Research Institution: Hiroshima University
• Principal Investigator: Yoshimura Yukinori 広島大学, 生物圏科学研究科, 教授 (10167017)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ニワトリ / 消化管 / プロバイオティクス / 抗菌ペプチド / 炎症性サイトカイン

Outline of Final Research Achievements

The results of current study showed that probiotics feeding enhanced the responsiveness to Salmonella lipopolysaccharide for induction of expression of 6 avian β-defensins　(AvBDs) and 2 cathelicidins in the chick cecum. However, probiotics feeding did not affect significantly the expression of inflammatory cytokines. There are reports showing that probiotics regulate the microflora in the intestine to suppress infection by pathogenic microorganisms, whereas the current study suggests that probiotics enhances the functions to synthesize AvBDs and CATHs. It is suggested that probiotics enhances the innate immunity by antimicrobial peptides in the gut, leading to enhancement of defense ability against pathogenic microbes.

Free Research Field

家畜生体機構学