2014 Fiscal Year Final Research Report
Experimental mouse model for influenza-associated encephalopathy
| Project/Area Number |
25660221
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Tottori University |
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Principal Investigator |
SUNDEN Yuji 鳥取大学, 農学部, 准教授 (20451403)
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| Research Collaborator |
OICHI Marino
SODA Kosuke
MORITA Takehito
HASHIGUCHI Miteki
SEKIGUCHI Yuka
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | pathology / influenza / virus / encephalopathy / mouse / cytokine |
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| Outline of Final Research Achievements |
Influenza-associated encephalopathy (IAE) is a severe neurological disease of infant. The pathogenesis of IAE is not well known and no effective preventive/therapeutic treatment is established. The purpose of present study is to establish a mouse model of IAE through influenza virus challenge experiment. It is demonstrated that the virus-inoculated mouse showed respiratory disease including pneumonia, however, no evidence of neurological disorders and/or brain lesions are observed. Further, direct inoculation of a few viral antigens into brain parenchyma induced high cytokine profiles those are partly similar to the findings of IAE patients.
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| Free Research Field |
獣医病理学
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