Mechanism of turnout switch for cell death

2014 Fiscal Year Final Research Report

• Project/Area Number: 25660227
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Yamaguchi University
• Principal Investigator: OHAMA Takashi 山口大学, 獣医学部, 准教授 (50579018)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 細胞死 / アポトーシス / オートファジー / ホスファターゼ

Outline of Final Research Achievements

There are two types of programed cell death, called apoptosis and autophagy. The purpose of this project is to clarify the mechanism of turnout switch for cells selecting the way to die. We focused on type2A protein phosphatase family, PP2A and PP6, and Beclin 1 that plays important roles for both apoptosis and autophagy. We performed 1) Identification of novel phospho-site of Beclin 1 and its functional analysis, 2) Analysis for the regulatory mechanism of Beclin 1 complex composition by PP6, 3) Analysis for the regulatory mechanism of apoptosis by PP2A.

Free Research Field

獣医薬理学