2014 Fiscal Year Final Research Report
In vivo molecular imaging of viral encephalitis
| Project/Area Number |
25660229
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUCHIGAMI Takeshi 長崎大学, 医歯薬総合研究科(薬学系), 准教授 (30432206)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 分子イメージング / 日本脳炎ウイルス / ダニ媒介性脳炎ウイルス / ナイロウイルス / SFTSウイルス / マウス / 18F-FDG / ポジトロン断層法(PET) |
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| Outline of Final Research Achievements |
In this study, we demonstrated in vivo molecular imaging of virus-infected mice. We inoculated encephalitis viruses (Japanese encephalitis virus and Tick-borne encephalitis virus), Severe fever with thrombocytopenia virus (SFTSV) and newly isolated Nairovirus (TFLV) in each susceptible mouse. Following encephalitis virus infections, decrease of 18F-FDG uptakes were observed in the brains of virus-infected mice compared with mock-infected mice. On the other hand, following infections with SFTSV and TFLV, significant uptakes of 18F-FDG were observed in the small intestines of virus-infected mice but not in mock-infected mice. These data will provide useful information for further study of molecular imaging in the field of virology.
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| Free Research Field |
ウイルス学、獣医学
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